[Download] "Toward Broader Inclusion of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory (Editorials)" by Clinical Chemistry ~ eBook PDF Kindle ePub Free
eBook details
- Title: Toward Broader Inclusion of Liquid Chromatography-Mass Spectrometry in the Clinical Laboratory (Editorials)
- Author : Clinical Chemistry
- Release Date : January 01, 2004
- Genre: Chemistry,Books,Science & Nature,
- Pages : * pages
- Size : 176 KB
Description
Mass spectrometry is widely appreciated as a powerful analytical method, characterized by high sensitivity and high information content, that can be used for both the qualitative and quantitative analysis of nearly all types of molecules. In light of this power, I would propose that mass spectrometry is ready for a substantially larger role in routine clinical analyses. In this issue of Clinical Chemistry, Muddiman and coworkers from the Mayo Clinic present reports in which two levels of mass spectrometry experiments are used to detect and characterize transthyretin variants by accurately measuring the molecular mass of the intact protein isolated from human serum (1, 2). As described by the authors, transthyretin variants can form amyloid in tissues that may ultimately damage those tissues. Currently, diagnosis is generally made after symptoms appear by detecting the amyloid in biopsies of the affected tissue.